Drug interactions
Maprotiline + Orphenadrine
Severity: Moderate
Maprotiline and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity and cause sedation. Together they can produce dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older adults. Sedation and cognitive impairment may also be increased.
What this interaction means in plain words
Maprotiline and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation and confusion, and reduce doses or choose alternatives in older patients or those with glaucoma or prostatic hypertrophy. Advise against driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Orphenadrine?
MediHelp rates the interaction as moderate. Maprotiline and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity and cause sedation. Together they can produce dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older adults. Sedation and cognitive impairment may also be increased.
How serious is the interaction between Maprotiline and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation and confusion, and reduce doses or choose alternatives in older patients or those with glaucoma or prostatic hypertrophy. Advise against driving if drowsy.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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