Drug interactions
Maprotiline + Papaveretum
Severity: Moderate
Maprotiline and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opium alkaloid mixture containing morphine, which causes sedation and respiratory depression. Combined with sedating maprotiline, drowsiness and impaired alertness are increased, and breathing may be depressed.
What this interaction means in plain words
Maprotiline and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and the sedative properties of maprotiline.
What to do
Start with reduced opioid doses and monitor sedation level and respiratory rate. Warn patients against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Papaveretum?
MediHelp rates the interaction as moderate. Maprotiline and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum is an opium alkaloid mixture containing morphine, which causes sedation and respiratory depression. Combined with sedating maprotiline, drowsiness and impaired alertness are increased, and breathing may be depressed.
How serious is the interaction between Maprotiline and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced opioid doses and monitor sedation level and respiratory rate. Warn patients against driving and alcohol use.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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