Drug interactions
Maprotiline + Pholcodine
Severity: Minor
Maprotiline and Pholcodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive with mild sedative properties. With maprotiline, drowsiness may be increased, though at antitussive doses the effect is usually modest.
What this interaction means in plain words
Maprotiline and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects of an opioid and a sedating antidepressant.
What to do
Counsel patients about additive drowsiness and advise caution with driving and alcohol. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Pholcodine?
MediHelp rates the interaction as minor. Maprotiline and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid antitussive with mild sedative properties. With maprotiline, drowsiness may be increased, though at antitussive doses the effect is usually modest.
How serious is the interaction between Maprotiline and Pholcodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and advise caution with driving and alcohol. No dose change is usually needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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