Drug interactions
Maprotiline + Procainamide
Severity: Contraindicated
Maprotiline and Procainamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lengthen the QT interval and slow cardiac conduction, so together they raise the risk of torsades de pointes and conduction disturbances. The risk is higher with renal impairment, electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Maprotiline and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic effects on QT prolongation and cardiac conduction.
What to do
Avoid combining them and select an antidepressant with less cardiac effect if procainamide is required. If unavoidable, monitor ECG (QTc and QRS) and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Procainamide?
MediHelp rates the interaction as contraindicated. Maprotiline and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can lengthen the QT interval and slow cardiac conduction, so together they raise the risk of torsades de pointes and conduction disturbances. The risk is higher with renal impairment, electrolyte disturbances or underlying heart disease.
How serious is the interaction between Maprotiline and Procainamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them and select an antidepressant with less cardiac effect if procainamide is required. If unavoidable, monitor ECG (QTc and QRS) and correct potassium and magnesium.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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