Drug interactions
Maprotiline + Promazine
Severity: Major
Maprotiline and Promazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, raising the risk of torsades de pointes. Promazine can also inhibit CYP2D6 and add anticholinergic, sedative and seizure-threshold effects.
What this interaction means in plain words
Maprotiline and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation via cardiac potassium channel blockade, with possible CYP2D6-mediated increases in maprotiline levels.
What to do
Avoid if possible. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for sedation and seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Promazine?
MediHelp rates the interaction as major. Maprotiline and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, raising the risk of torsades de pointes. Promazine can also inhibit CYP2D6 and add anticholinergic, sedative and seizure-threshold effects.
How serious is the interaction between Maprotiline and Promazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for sedation and seizures.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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