Drug interactions
Maprotiline + Same
Severity: Moderate
Maprotiline and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has reported serotonergic effects, and combining it with antidepressants may increase the risk of serotonin toxicity. Data are limited, and the risk with maprotiline is likely modest.
What this interaction means in plain words
Maprotiline and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; the mechanism is not firmly established.
What to do
Avoid starting SAMe without clinician oversight. If combined, monitor for agitation, tremor, diarrhea and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Same?
MediHelp rates the interaction as moderate. Maprotiline and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) has reported serotonergic effects, and combining it with antidepressants may increase the risk of serotonin toxicity. Data are limited, and the risk with maprotiline is likely modest.
How serious is the interaction between Maprotiline and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting SAMe without clinician oversight. If combined, monitor for agitation, tremor, diarrhea and hyperthermia.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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