Drug interactions
Maprotiline + Scullcap
Severity: Minor
Maprotiline and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal preparations are traditionally used for calming effects and may cause sedation. Combined with maprotiline, drowsiness may be increased, though clinical data are limited.
What this interaction means in plain words
Maprotiline and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedation from GABAergic activity of skullcap constituents; poorly characterized.
What to do
Advise patients to report increased drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Scullcap?
MediHelp rates the interaction as minor. Maprotiline and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap herbal preparations are traditionally used for calming effects and may cause sedation. Combined with maprotiline, drowsiness may be increased, though clinical data are limited.
How serious is the interaction between Maprotiline and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report increased drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation is excessive.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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