Drug interactions
Maprotiline + Selegiline transdermal
Severity: Contraindicated
Maprotiline and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO, and combining it with a noradrenergic antidepressant can cause hypertensive crisis and serotonin syndrome. Labeling recommends against concurrent use of tricyclic-type antidepressants.
What this interaction means in plain words
Maprotiline and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition by selegiline combined with norepinephrine reuptake blockade by maprotiline leads to excess monoamines.
What to do
Do not use together. Allow an adequate washout between the drugs, as specified in the product labeling, when switching.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Maprotiline and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline at antidepressant doses inhibits MAO, and combining it with a noradrenergic antidepressant can cause hypertensive crisis and serotonin syndrome. Labeling recommends against concurrent use of tricyclic-type antidepressants.
How serious is the interaction between Maprotiline and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow an adequate washout between the drugs, as specified in the product labeling, when switching.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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