Drug interactions
Maprotiline + Sufentanil sl
Severity: Major
Maprotiline and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil is a potent opioid that causes sedation and respiratory depression, which maprotiline can add to. Antidepressants may also rarely contribute to serotonin syndrome with opioids.
What this interaction means in plain words
Maprotiline and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with possible minor serotonergic contribution.
What to do
Monitor sedation and respiratory function closely, especially at initiation and dose changes, and watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Sufentanil sl?
MediHelp rates the interaction as major. Maprotiline and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil is a potent opioid that causes sedation and respiratory depression, which maprotiline can add to. Antidepressants may also rarely contribute to serotonin syndrome with opioids.
How serious is the interaction between Maprotiline and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function closely, especially at initiation and dose changes, and watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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