Drug interactions
Maprotiline + Sumatriptan intranasal
Severity: Moderate
Maprotiline and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase serotonergic activity, so using them together could rarely cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Maprotiline mainly inhibits norepinephrine reuptake, so the serotonergic contribution is modest and the risk is low.
What this interaction means in plain words
Maprotiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects (5-HT1B/1D agonism plus antidepressant reuptake inhibition).
What to do
Counsel the patient on serotonin syndrome symptoms and monitor for them after starting or increasing either drug. Stop both and treat supportively if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Maprotiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase serotonergic activity, so using them together could rarely cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Maprotiline mainly inhibits norepinephrine reuptake, so the serotonergic contribution is modest and the risk is low.
How serious is the interaction between Maprotiline and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on serotonin syndrome symptoms and monitor for them after starting or increasing either drug. Stop both and treat supportively if symptoms appear.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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