Drug interactions
Maprotiline + Terbutaline
Severity: Moderate
Maprotiline and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can potentiate the cardiovascular effects of terbutaline, with tachycardia and arrhythmia. The risk is higher with systemic terbutaline and in patients with heart disease.
What this interaction means in plain words
Maprotiline and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Terbutaline belongs to Respiratory.
Why it happens
Maprotiline blocks norepinephrine reuptake and has additive adrenergic and QT-prolonging effects with beta-agonist-induced tachycardia and hypokalemia.
What to do
Monitor heart rate, rhythm and potassium, particularly with oral or parenteral terbutaline. Obtain an ECG in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Terbutaline?
MediHelp rates the interaction as moderate. Maprotiline and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can potentiate the cardiovascular effects of terbutaline, with tachycardia and arrhythmia. The risk is higher with systemic terbutaline and in patients with heart disease.
How serious is the interaction between Maprotiline and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and potassium, particularly with oral or parenteral terbutaline. Obtain an ECG in patients with cardiac disease.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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