Drug interactions
Maprotiline + Thiothixene
Severity: Moderate
Maprotiline and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with sedative, anticholinergic and seizure-threshold lowering properties. With maprotiline, sedation and anticholinergic effects are increased, and seizure risk and QT prolongation may rise. Maprotiline may also raise antipsychotic levels through CYP2D6 inhibition.
What this interaction means in plain words
Maprotiline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, antimuscarinic effects and seizure threshold lowering, with possible CYP2D6 inhibition.
What to do
Monitor sedation, anticholinergic effects and seizure risk, and obtain an ECG if other QT risk factors are present. Adjust doses downward if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Thiothixene?
MediHelp rates the interaction as moderate. Maprotiline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with sedative, anticholinergic and seizure-threshold lowering properties. With maprotiline, sedation and anticholinergic effects are increased, and seizure risk and QT prolongation may rise. Maprotiline may also raise antipsychotic levels through CYP2D6 inhibition.
How serious is the interaction between Maprotiline and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic effects and seizure risk, and obtain an ECG if other QT risk factors are present. Adjust doses downward if adverse effects appear.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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