Drug interactions
Maprotiline + Topiramate
Severity: Moderate
Maprotiline and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and cognitive slowing, so together they may increase sedation and impair concentration. Maprotiline also lowers the seizure threshold, which may counteract topiramate when it is used for epilepsy.
What this interaction means in plain words
Maprotiline and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression, with maprotiline lowering the seizure threshold.
What to do
Monitor for excessive sedation and cognitive effects, and caution patients about driving. In patients with epilepsy, monitor seizure control or choose an antidepressant with lower seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Maprotiline with Topiramate?
MediHelp rates the interaction as moderate. Maprotiline and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and cognitive slowing, so together they may increase sedation and impair concentration. Maprotiline also lowers the seizure threshold, which may counteract topiramate when it is used for epilepsy.
How serious is the interaction between Maprotiline and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive effects, and caution patients about driving. In patients with epilepsy, monitor seizure control or choose an antidepressant with lower seizure risk.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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