Drug interactions
Maprotiline + Triclofos
Severity: Moderate
Maprotiline and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and maprotiline is a sedating tetracyclic antidepressant. Combined use can cause excessive drowsiness, confusion and impaired alertness.
What this interaction means in plain words
Maprotiline and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Start with the lowest triclofos dose and monitor for oversedation and falls. Advise against driving or operating machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Triclofos?
MediHelp rates the interaction as moderate. Maprotiline and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and maprotiline is a sedating tetracyclic antidepressant. Combined use can cause excessive drowsiness, confusion and impaired alertness.
How serious is the interaction between Maprotiline and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest triclofos dose and monitor for oversedation and falls. Advise against driving or operating machinery until the response is known.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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