Drug interactions
Maprotiline + Trihexyphenidyl
Severity: Moderate
Maprotiline and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combining them can cause additive effects such as dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Older patients are especially vulnerable to delirium and ileus.
What this interaction means in plain words
Maprotiline and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, particularly cognitive effects and urinary retention, and use the lowest effective doses. Consider a less anticholinergic antidepressant in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Trihexyphenidyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Maprotiline with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Maprotiline and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combining them can cause additive effects such as dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Older patients are especially vulnerable to delirium and ileus.
How serious is the interaction between Maprotiline and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly cognitive effects and urinary retention, and use the lowest effective doses. Consider a less anticholinergic antidepressant in older patients.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
