Drug interactions
Maprotiline + Triprolidine
Severity: Moderate
Maprotiline and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant with anticholinergic activity, and triprolidine increases both drowsiness and antimuscarinic effects. Confusion, dry mouth, urinary retention and constipation may result, especially in older adults.
What this interaction means in plain words
Maprotiline and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation and anticholinergic toxicity, and choose a non-sedating antihistamine if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Triprolidine?
MediHelp rates the interaction as moderate. Maprotiline and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant with anticholinergic activity, and triprolidine increases both drowsiness and antimuscarinic effects. Confusion, dry mouth, urinary retention and constipation may result, especially in older adults.
How serious is the interaction between Maprotiline and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic toxicity, and choose a non-sedating antihistamine if possible.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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