Drug interactions
Maprotiline + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Maprotiline and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants can potentiate the cardiovascular effects of the long-acting beta-agonist vilanterol, including QTc prolongation, tachycardia and arrhythmias. Inhaled doses are low, so the effect is usually modest.
What this interaction means in plain words
Maprotiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and potentiation of beta-adrenergic cardiovascular effects.
What to do
Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Choose an alternative bronchodilator if QTc prolongation is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Maprotiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic-type antidepressants can potentiate the cardiovascular effects of the long-acting beta-agonist vilanterol, including QTc prolongation, tachycardia and arrhythmias. Inhaled doses are low, so the effect is usually modest.
How serious is the interaction between Maprotiline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Choose an alternative bronchodilator if QTc prolongation is significant.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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