Drug interactions
Maprotiline + Yohimbe
Severity: Major
Maprotiline and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine, the active alkaloid in yohimbe, is an alpha-2 antagonist that raises sympathetic outflow and can cause hypertension, tachycardia and anxiety. Maprotiline blocks norepinephrine reuptake, so combined use may exaggerate noradrenergic effects and produce unpredictable blood pressure changes.
What this interaction means in plain words
Maprotiline and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic effects from alpha-2 antagonism and norepinephrine reuptake inhibition; the exact interaction is not fully characterised.
What to do
Advise patients to avoid yohimbe products while on maprotiline. If exposure has occurred, monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Yohimbe?
MediHelp rates the interaction as major. Maprotiline and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine, the active alkaloid in yohimbe, is an alpha-2 antagonist that raises sympathetic outflow and can cause hypertension, tachycardia and anxiety. Maprotiline blocks norepinephrine reuptake, so combined use may exaggerate noradrenergic effects and produce unpredictable blood pressure changes.
How serious is the interaction between Maprotiline and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while on maprotiline. If exposure has occurred, monitor blood pressure and heart rate.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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