Drug interactions
Maprotiline + Yohimbine
Severity: Moderate
Maprotiline and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline blocks norepinephrine reuptake, and yohimbine is an alpha-2 antagonist that increases noradrenergic outflow. Together they can cause exaggerated sympathetic effects such as hypertension, tachycardia, anxiety and tremor. Maprotiline also lowers the seizure threshold, adding a further risk.
What this interaction means in plain words
Maprotiline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive noradrenergic stimulation through reuptake inhibition (maprotiline) and presynaptic alpha-2 blockade (yohimbine).
What to do
Avoid the combination where possible, or monitor blood pressure and heart rate and watch for agitation or palpitations. Reduce or stop yohimbine if pressor effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Yohimbine?
MediHelp rates the interaction as moderate. Maprotiline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline blocks norepinephrine reuptake, and yohimbine is an alpha-2 antagonist that increases noradrenergic outflow. Together they can cause exaggerated sympathetic effects such as hypertension, tachycardia, anxiety and tremor. Maprotiline also lowers the seizure threshold, adding a further risk.
How serious is the interaction between Maprotiline and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood pressure and heart rate and watch for agitation or palpitations. Reduce or stop yohimbine if pressor effects occur.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
