Drug interactions
Maribavir + Phenytoin
Severity: Moderate
Maribavir and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin lowers maribavir concentrations and may compromise control of CMV infection.
What this interaction means in plain words
Maribavir and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maribavir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing maribavir metabolism.
What to do
If coadministration is needed, increase the maribavir dose as directed by labeling and monitor CMV viral load. Consider a non-inducing anticonvulsant where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maribavir
- Ganciclovir + Maribavir Major
- Maribavir + Rifampicin Major
- Maribavir + Valganciclovir Major
- Carbamazepine + Maribavir Moderate
- Digoxin + Maribavir Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Maribavir with Phenytoin?
MediHelp rates the interaction as moderate. Maribavir and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin lowers maribavir concentrations and may compromise control of CMV infection.
How serious is the interaction between Maribavir and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, increase the maribavir dose as directed by labeling and monitor CMV viral load. Consider a non-inducing anticonvulsant where possible.
What other medicines interact with Maribavir?
MediHelp also lists interactions of Maribavir with, for example, Ganciclovir, Rifampicin, Valganciclovir. The full list is on the Maribavir page.
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