Drug interactions
Maribavir + Rifampicin
Severity: Major
Maribavir and Rifampicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin substantially reduces maribavir exposure, risking loss of antiviral efficacy and CMV breakthrough.
What this interaction means in plain words
Maribavir and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maribavir belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin is a potent CYP3A4 inducer that accelerates maribavir clearance.
What to do
Avoid the combination and use an alternative antimycobacterial agent if feasible. If unavoidable, monitor CMV viral load closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maribavir
- Ganciclovir + Maribavir Major
- Maribavir + Valganciclovir Major
- Carbamazepine + Maribavir Moderate
- Digoxin + Maribavir Moderate
- Maribavir + Phenytoin Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Maribavir with Rifampicin?
MediHelp rates the interaction as major. Maribavir and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin substantially reduces maribavir exposure, risking loss of antiviral efficacy and CMV breakthrough.
How serious is the interaction between Maribavir and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimycobacterial agent if feasible. If unavoidable, monitor CMV viral load closely.
What other medicines interact with Maribavir?
MediHelp also lists interactions of Maribavir with, for example, Ganciclovir, Valganciclovir, Carbamazepine. The full list is on the Maribavir page.
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