Drug interactions
Digoxin + Maribavir
Severity: Moderate
Digoxin and Maribavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maribavir raises digoxin concentrations. Because digoxin has a narrow therapeutic index, this can lead to toxicity such as arrhythmias, nausea and visual disturbances.
What this interaction means in plain words
Digoxin and Maribavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Maribavir belongs to Anti Virals.
Why it happens
Maribavir inhibits intestinal P-glycoprotein, increasing digoxin absorption.
What to do
Monitor serum digoxin concentrations and clinical signs of toxicity when starting or stopping maribavir. Reduce the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maribavir
- Ganciclovir + Maribavir Major
- Maribavir + Rifampicin Major
- Maribavir + Valganciclovir Major
- Carbamazepine + Maribavir Moderate
- Maribavir + Phenytoin Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Maribavir?
MediHelp rates the interaction as moderate. Digoxin and Maribavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maribavir raises digoxin concentrations. Because digoxin has a narrow therapeutic index, this can lead to toxicity such as arrhythmias, nausea and visual disturbances.
How serious is the interaction between Digoxin and Maribavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical signs of toxicity when starting or stopping maribavir. Reduce the digoxin dose if needed.
What other medicines interact with Maribavir?
MediHelp also lists interactions of Maribavir with, for example, Ganciclovir, Rifampicin, Valganciclovir. The full list is on the Maribavir page.
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