Drug interactions
Marijuana + Metaxalone
Severity: Moderate
Marijuana and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause drowsiness, dizziness and slowed psychomotor performance, and metaxalone has similar effects. Used together, they may increase impairment and the risk of falls or accidents.
What this interaction means in plain words
Marijuana and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects through different pathways.
What to do
Advise the patient to avoid driving or operating machinery and to limit cannabis use while taking metaxalone. Monitor for excessive sedation and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Marijuana with Metaxalone?
MediHelp rates the interaction as moderate. Marijuana and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can cause drowsiness, dizziness and slowed psychomotor performance, and metaxalone has similar effects. Used together, they may increase impairment and the risk of falls or accidents.
How serious is the interaction between Marijuana and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid driving or operating machinery and to limit cannabis use while taking metaxalone. Monitor for excessive sedation and confusion.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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