Drug interactions
Marijuana + Mexiletine
Severity: Minor
Marijuana and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids can inhibit CYP enzymes in vitro, and smoked cannabis also induces CYP1A2, so effects on mexiletine are unpredictable. Additive dizziness and CNS effects are also possible.
What this interaction means in plain words
Marijuana and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoid inhibition of CYP2D6 is suggested in vitro, while smoke induces CYP1A2; net effect is unclear.
What to do
Advise patients about additive dizziness or impaired alertness, and monitor mexiletine response and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Marijuana with Mexiletine?
MediHelp rates the interaction as minor. Marijuana and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids can inhibit CYP enzymes in vitro, and smoked cannabis also induces CYP1A2, so effects on mexiletine are unpredictable. Additive dizziness and CNS effects are also possible.
How serious is the interaction between Marijuana and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about additive dizziness or impaired alertness, and monitor mexiletine response and adverse effects.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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