Drug interactions
Marijuana + Nalbuphine
Severity: Moderate
Marijuana and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can add to opioid-induced drowsiness, dizziness and impaired psychomotor performance. The combination may increase the risk of falls and accidents.
What this interaction means in plain words
Marijuana and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of cannabinoid receptor activation and opioid receptor activity.
What to do
Advise patients to avoid driving or hazardous tasks and to report excessive sedation. Monitor alertness and consider a lower nalbuphine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Marijuana with Nalbuphine?
MediHelp rates the interaction as moderate. Marijuana and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can add to opioid-induced drowsiness, dizziness and impaired psychomotor performance. The combination may increase the risk of falls and accidents.
How serious is the interaction between Marijuana and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks and to report excessive sedation. Monitor alertness and consider a lower nalbuphine dose.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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