Drug interactions
Marijuana + Nicardipine
Severity: Minor
Marijuana and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause tachycardia and orthostatic hypotension, which may add to the vasodilatory effects of nicardipine. Cannabidiol inhibits CYP3A4 in vitro, so nicardipine levels could rise, but clinical data are limited.
What this interaction means in plain words
Marijuana and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hemodynamic effects, plus possible CYP3A4 inhibition by cannabinoids that is not well established clinically.
What to do
Counsel the patient about dizziness and fast heartbeat, and monitor blood pressure and heart rate. Adjust nicardipine only if symptomatic hypotension or tachycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Marijuana with Nicardipine?
MediHelp rates the interaction as minor. Marijuana and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis can cause tachycardia and orthostatic hypotension, which may add to the vasodilatory effects of nicardipine. Cannabidiol inhibits CYP3A4 in vitro, so nicardipine levels could rise, but clinical data are limited.
How serious is the interaction between Marijuana and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness and fast heartbeat, and monitor blood pressure and heart rate. Adjust nicardipine only if symptomatic hypotension or tachycardia occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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