Drug interactions
Marijuana + Nimodipine
Severity: Minor
Marijuana and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids may inhibit CYP3A4 in vitro and could modestly raise nimodipine levels. Cannabis can also cause tachycardia and orthostatic hypotension, which may add to nimodipine effects.
What this interaction means in plain words
Marijuana and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids plus additive cardiovascular effects; clinical data are limited.
What to do
Monitor blood pressure and heart rate in patients who use cannabis. Counsel about dizziness on standing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Marijuana with Nimodipine?
MediHelp rates the interaction as minor. Marijuana and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids may inhibit CYP3A4 in vitro and could modestly raise nimodipine levels. Cannabis can also cause tachycardia and orthostatic hypotension, which may add to nimodipine effects.
How serious is the interaction between Marijuana and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate in patients who use cannabis. Counsel about dizziness on standing.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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