Drug interactions
Marijuana + Oxymorphone
Severity: Moderate
Marijuana and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis has sedative and psychomotor-impairing effects that add to opioid-induced drowsiness, dizziness and respiratory depression. Cognitive impairment and falls may be more likely, particularly in older patients.
What this interaction means in plain words
Marijuana and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of THC and mu-opioid agonism.
What to do
Counsel patients about additive sedation and impaired driving, and monitor for oversedation after changes in cannabis use. Reduce the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Marijuana with Oxymorphone?
MediHelp rates the interaction as moderate. Marijuana and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis has sedative and psychomotor-impairing effects that add to opioid-induced drowsiness, dizziness and respiratory depression. Cognitive impairment and falls may be more likely, particularly in older patients.
How serious is the interaction between Marijuana and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive sedation and impaired driving, and monitor for oversedation after changes in cannabis use. Reduce the opioid dose if excessive drowsiness occurs.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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