Drug interactions
Marijuana + Repaglinide
Severity: Minor
Marijuana and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids may inhibit CYP enzymes and could raise repaglinide levels, while cannabis use can also affect appetite and glucose handling. The net effect on glycemic control is unpredictable.
What this interaction means in plain words
Marijuana and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoids may inhibit CYP3A4 and CYP2C8 in vitro and may alter glucose regulation; clinical significance is not well established.
What to do
Monitor blood glucose in patients who use cannabis regularly and counsel them about irregular eating, which increases hypoglycemia risk with repaglinide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Marijuana with Repaglinide?
MediHelp rates the interaction as minor. Marijuana and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids may inhibit CYP enzymes and could raise repaglinide levels, while cannabis use can also affect appetite and glucose handling. The net effect on glycemic control is unpredictable.
How serious is the interaction between Marijuana and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose in patients who use cannabis regularly and counsel them about irregular eating, which increases hypoglycemia risk with repaglinide.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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