Drug interactions
Marijuana + Simvastatin
Severity: Minor
Marijuana and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, which might raise simvastatin exposure. Clinical data with smoked or recreational cannabis are limited and no important effect has been established.
What this interaction means in plain words
Marijuana and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoids may weakly inhibit CYP3A4, but clinical significance is unproven.
What to do
No dose change is needed. Advise the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Marijuana with Simvastatin?
MediHelp rates the interaction as minor. Marijuana and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, which might raise simvastatin exposure. Clinical data with smoked or recreational cannabis are limited and no important effect has been established.
How serious is the interaction between Marijuana and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Advise the patient to report unexplained muscle pain or weakness.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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