Drug interactions
Marijuana + Ziprasidone
Severity: Moderate
Marijuana and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can add to the sedation and dizziness caused by ziprasidone and may impair psychomotor performance. Cannabis may also worsen psychotic symptoms in susceptible patients. Tachycardia from cannabis may add to cardiovascular strain.
What this interaction means in plain words
Marijuana and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through CB1 receptor effects and antipsychotic sedation.
What to do
Advise patients to avoid driving or operating machinery and to limit cannabis use. Monitor psychiatric status and adherence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Marijuana with Ziprasidone?
MediHelp rates the interaction as moderate. Marijuana and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can add to the sedation and dizziness caused by ziprasidone and may impair psychomotor performance. Cannabis may also worsen psychotic symptoms in susceptible patients. Tachycardia from cannabis may add to cardiovascular strain.
How serious is the interaction between Marijuana and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or operating machinery and to limit cannabis use. Monitor psychiatric status and adherence.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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