Drug interactions
Mavacamten + Metformin-pioglitazone
Severity: Minor
Mavacamten and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized in part by CYP2C19, and inhibitors can raise its levels. Pioglitazone is not a well-established CYP2C19 inhibitor, so any effect is likely small. Higher mavacamten exposure could reduce ejection fraction and cause heart failure symptoms.
What this interaction means in plain words
Mavacamten and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mavacamten belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible weak CYP2C19 inhibition reducing mavacamten metabolism; not firmly established.
What to do
Monitor left ventricular ejection fraction and clinical status per mavacamten labeling when pioglitazone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Mavacamten and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is metabolized in part by CYP2C19, and inhibitors can raise its levels. Pioglitazone is not a well-established CYP2C19 inhibitor, so any effect is likely small. Higher mavacamten exposure could reduce ejection fraction and cause heart failure symptoms.
How serious is the interaction between Mavacamten and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status per mavacamten labeling when pioglitazone is started or stopped.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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