Drug interactions
Mavacamten + Oxcarbazepine
Severity: Moderate
Mavacamten and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4. Oxcarbazepine can inhibit CYP2C19 but also induces CYP3A4, so the net effect on mavacamten exposure is uncertain and the legacy direction is not well established.
What this interaction means in plain words
Mavacamten and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine has opposing effects, weakly inhibiting CYP2C19 while inducing CYP3A4, so the net effect on mavacamten is unclear.
What to do
Monitor LVEF and clinical response with echocardiography when oxcarbazepine is started or stopped, and adjust the mavacamten dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Oxcarbazepine?
MediHelp rates the interaction as moderate. Mavacamten and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4. Oxcarbazepine can inhibit CYP2C19 but also induces CYP3A4, so the net effect on mavacamten exposure is uncertain and the legacy direction is not well established.
How serious is the interaction between Mavacamten and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical response with echocardiography when oxcarbazepine is started or stopped, and adjust the mavacamten dose per labeling.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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