Drug interactions
Mavacamten + Pantoprazole
Severity: Moderate
Mavacamten and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19, and higher exposure can reduce ejection fraction and cause systolic heart failure. Pantoprazole is only a weak CYP2C19 inhibitor, so the effect is likely small, but omeprazole and esomeprazole are the PPIs of main concern.
What this interaction means in plain words
Mavacamten and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak inhibition of CYP2C19-mediated mavacamten metabolism.
What to do
Monitor LVEF and clinical status per mavacamten protocol when PPIs are started or stopped. Pantoprazole is preferred over omeprazole or esomeprazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Pantoprazole?
MediHelp rates the interaction as moderate. Mavacamten and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized mainly by CYP2C19, and higher exposure can reduce ejection fraction and cause systolic heart failure. Pantoprazole is only a weak CYP2C19 inhibitor, so the effect is likely small, but omeprazole and esomeprazole are the PPIs of main concern.
How serious is the interaction between Mavacamten and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status per mavacamten protocol when PPIs are started or stopped. Pantoprazole is preferred over omeprazole or esomeprazole.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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