Drug interactions
Mavacamten + Timolol
Severity: Major
Mavacamten and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and timolol has negative inotropic and chronotropic effects. Together they may precipitate heart failure with reduced ejection fraction. Beta-blockers are often used in obstructive hypertrophic cardiomyopathy, so the combination needs oversight.
What this interaction means in plain words
Mavacamten and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects.
What to do
Monitor LVEF and clinical heart failure signs per mavacamten labeling, and interrupt mavacamten if systolic function falls. Reassess the need for timolol, particularly systemic use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Timolol?
MediHelp rates the interaction as major. Mavacamten and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten reduces cardiac contractility and timolol has negative inotropic and chronotropic effects. Together they may precipitate heart failure with reduced ejection fraction. Beta-blockers are often used in obstructive hypertrophic cardiomyopathy, so the combination needs oversight.
How serious is the interaction between Mavacamten and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical heart failure signs per mavacamten labeling, and interrupt mavacamten if systolic function falls. Reassess the need for timolol, particularly systemic use.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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