Drug interactions
Measles mumps and rubella vaccine + Tocilizumab
Severity: Major
Measles mumps and rubella vaccine and Tocilizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab blocks interleukin-6 signaling and raises infection risk. Live vaccines may produce a weaker response and there are no safety data supporting their use. Labeling advises avoiding live vaccines during treatment.
What this interaction means in plain words
Measles mumps and rubella vaccine and Tocilizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tocilizumab belongs to Musculoskeletal.
Why it happens
IL-6 receptor blockade modifies immune responses, which may impair control of live attenuated virus.
What to do
Avoid live vaccines during tocilizumab therapy. Complete vaccinations before starting where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Tocilizumab?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Tocilizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tocilizumab blocks interleukin-6 signaling and raises infection risk. Live vaccines may produce a weaker response and there are no safety data supporting their use. Labeling advises avoiding live vaccines during treatment.
How serious is the interaction between Measles mumps and rubella vaccine and Tocilizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during tocilizumab therapy. Complete vaccinations before starting where possible.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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