Drug interactions
Measles mumps and rubella vaccine live + Obinutuzumab
Severity: Major
Measles mumps and rubella vaccine live and Obinutuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The MMR vaccine contains live attenuated viruses that may cause disease in patients with B-cell depletion. Protective antibody responses are also likely to be reduced.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Obinutuzumab depletes B cells, impairing immune control of live viruses and vaccine response.
What to do
Do not give MMR during obinutuzumab treatment or until B-cell recovery. Vaccinate at least 4 weeks before therapy when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Obinutuzumab?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine live and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The MMR vaccine contains live attenuated viruses that may cause disease in patients with B-cell depletion. Protective antibody responses are also likely to be reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Obinutuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR during obinutuzumab treatment or until B-cell recovery. Vaccinate at least 4 weeks before therapy when possible.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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