Drug interactions
Measles mumps and rubella vaccine live + Procarbazine
Severity: Contraindicated
Measles mumps and rubella vaccine live and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine suppresses immunity, and the MMR vaccine contains live attenuated viruses. Vaccine viruses may disseminate and cause disease in the patient, and protection may not develop.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression allows uncontrolled replication of live attenuated viruses and blunts the immune response.
What to do
Do not give MMR during procarbazine therapy. Defer vaccination until immune function has recovered, generally at least 3 months after treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Procarbazine?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine suppresses immunity, and the MMR vaccine contains live attenuated viruses. Vaccine viruses may disseminate and cause disease in the patient, and protection may not develop.
How serious is the interaction between Measles mumps and rubella vaccine live and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR during procarbazine therapy. Defer vaccination until immune function has recovered, generally at least 3 months after treatment.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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