Drug interactions
Measles mumps rubella and varicella vaccine live + Procarbazine
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine suppresses immune function, and the MMRV vaccine contains live attenuated viruses including varicella. Disseminated vaccine-strain infection can occur in immunocompromised patients and the vaccine response is likely to be poor.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression permits uncontrolled replication of live vaccine viruses and reduces immunogenicity.
What to do
Do not give the vaccine during procarbazine therapy. Defer until immune recovery, generally at least 3 months after chemotherapy stops.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Procarbazine?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine suppresses immune function, and the MMRV vaccine contains live attenuated viruses including varicella. Disseminated vaccine-strain infection can occur in immunocompromised patients and the vaccine response is likely to be poor.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine during procarbazine therapy. Defer until immune recovery, generally at least 3 months after chemotherapy stops.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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