Drug interactions
Mecasermin + Metformin-pioglitazone
Severity: Moderate
Mecasermin and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin has insulin-like activity and can cause hypoglycemia, which may be enhanced when combined with antidiabetic drugs. Hypoglycemia is the most common adverse effect of mecasermin.
What this interaction means in plain words
Mecasermin and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mecasermin belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Additive glucose-lowering effects from IGF-1 receptor activation with insulin-like actions plus antidiabetic agents.
What to do
Give mecasermin with or shortly after a meal and monitor blood glucose frequently. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Mecasermin
Frequently asked questions
Can I take Mecasermin with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Mecasermin and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin has insulin-like activity and can cause hypoglycemia, which may be enhanced when combined with antidiabetic drugs. Hypoglycemia is the most common adverse effect of mecasermin.
How serious is the interaction between Mecasermin and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose frequently. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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