Drug interactions
Mecasermin + Metformin-repaglinide
Severity: Moderate
Mecasermin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering effects. Combined with repaglinide and metformin it can cause additive hypoglycemia.
What this interaction means in plain words
Mecasermin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mecasermin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
IGF-1 receptor activation produces insulin-like glucose uptake, adding to antidiabetic drug effects.
What to do
Give mecasermin with or shortly after a meal and monitor blood glucose, reducing antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Mecasermin
Frequently asked questions
Can I take Mecasermin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Mecasermin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering effects. Combined with repaglinide and metformin it can cause additive hypoglycemia.
How serious is the interaction between Mecasermin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose, reducing antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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