Drug interactions
Mechlorethamine + Trastuzumab
Severity: Moderate
Mechlorethamine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a strongly myelosuppressive alkylating agent. Given with trastuzumab, the rate of neutropenia and febrile neutropenia may be higher than with chemotherapy alone, raising infection risk.
What this interaction means in plain words
Mechlorethamine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression, as trastuzumab increases neutropenia when combined with myelosuppressive chemotherapy.
What to do
Monitor complete blood counts and neutrophil counts regularly during combined treatment. Educate the patient to report fever promptly and consider supportive care such as growth factors per guidelines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Trastuzumab?
MediHelp rates the interaction as moderate. Mechlorethamine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a strongly myelosuppressive alkylating agent. Given with trastuzumab, the rate of neutropenia and febrile neutropenia may be higher than with chemotherapy alone, raising infection risk.
How serious is the interaction between Mechlorethamine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neutrophil counts regularly during combined treatment. Educate the patient to report fever promptly and consider supportive care such as growth factors per guidelines.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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