Drug interactions
Meclizine + Methohexital
Severity: Moderate
Meclizine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic and meclizine is a sedating antihistamine. Together they may deepen sedation and prolong recovery, and can add to respiratory and cardiovascular depression.
What this interaction means in plain words
Meclizine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 blockade.
What to do
The anesthesia team should titrate methohexital to effect and monitor respiration and sedation depth. Allow extended recovery observation if meclizine was taken beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclizine and Methohexital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclizine
Other interactions of Methohexital
Frequently asked questions
Can I take Meclizine with Methohexital?
MediHelp rates the interaction as moderate. Meclizine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic and meclizine is a sedating antihistamine. Together they may deepen sedation and prolong recovery, and can add to respiratory and cardiovascular depression.
How serious is the interaction between Meclizine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The anesthesia team should titrate methohexital to effect and monitor respiration and sedation depth. Allow extended recovery observation if meclizine was taken beforehand.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
