Drug interactions
Meclizine + Neomycin
Severity: Minor
Meclizine and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antiemetic and antivertigo agent that may suppress nausea, dizziness and vertigo, which are early signs of aminoglycoside ototoxicity. With oral neomycin, systemic absorption is low, but ototoxicity can occur with prolonged use, renal impairment or damaged mucosa.
What this interaction means in plain words
Meclizine and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meclizine belongs to Respiratory; Neomycin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic masking of vestibular symptoms by meclizine; no pharmacokinetic interaction is established.
What to do
Where neomycin exposure is prolonged or systemic absorption is likely, monitor hearing and vestibular function by audiometry rather than relying on symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Neomycin?
MediHelp rates the interaction as minor. Meclizine and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclizine is an antiemetic and antivertigo agent that may suppress nausea, dizziness and vertigo, which are early signs of aminoglycoside ototoxicity. With oral neomycin, systemic absorption is low, but ototoxicity can occur with prolonged use, renal impairment or damaged mucosa.
How serious is the interaction between Meclizine and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where neomycin exposure is prolonged or systemic absorption is likely, monitor hearing and vestibular function by audiometry rather than relying on symptoms.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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