Drug interactions
Meclizine + Thioridazine
Severity: Moderate
Meclizine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedative and anticholinergic effects, so combined use can cause drowsiness, confusion, dry mouth, constipation and urinary retention. Older patients are most vulnerable, with greater risk of falls. Meclizine may also be metabolized by CYP2D6, which thioridazine inhibits, possibly raising its levels.
What this interaction means in plain words
Meclizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive H1 antagonism and muscarinic blockade, with possible CYP2D6 inhibition by thioridazine.
What to do
Monitor for oversedation and anticholinergic effects, and use the lowest effective meclizine dose. Prefer an alternative in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Thioridazine?
MediHelp rates the interaction as moderate. Meclizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative and anticholinergic effects, so combined use can cause drowsiness, confusion, dry mouth, constipation and urinary retention. Older patients are most vulnerable, with greater risk of falls. Meclizine may also be metabolized by CYP2D6, which thioridazine inhibits, possibly raising its levels.
How serious is the interaction between Meclizine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and use the lowest effective meclizine dose. Prefer an alternative in elderly patients.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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