Drug interactions
Meclizine + Ziprasidone
Severity: Moderate
Meclizine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an anticholinergic antihistamine that causes sedation, and combined with ziprasidone it may increase drowsiness, dizziness and anticholinergic effects such as dry mouth and constipation. Clinically significant reduction in ziprasidone absorption is not established.
What this interaction means in plain words
Meclizine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and anticholinergic effects (pharmacodynamic).
What to do
Monitor for excessive sedation, confusion and anticholinergic symptoms, particularly in older adults. Use the lowest effective meclizine dose or an alternative if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Ziprasidone?
MediHelp rates the interaction as moderate. Meclizine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an anticholinergic antihistamine that causes sedation, and combined with ziprasidone it may increase drowsiness, dizziness and anticholinergic effects such as dry mouth and constipation. Clinically significant reduction in ziprasidone absorption is not established.
How serious is the interaction between Meclizine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and anticholinergic symptoms, particularly in older adults. Use the lowest effective meclizine dose or an alternative if problems occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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