Drug interactions
Meclofenamate + Mesalamine
Severity: Moderate
Meclofenamate and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may harm the kidney: mesalamine through rare interstitial nephritis and meclofenamate through NSAID-induced reductions in renal blood flow. Together they may raise the risk of renal impairment.
What this interaction means in plain words
Meclofenamate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity involving NSAID prostaglandin inhibition and mesalamine-related interstitial injury.
What to do
Monitor serum creatinine periodically and ensure adequate hydration. Discontinue the NSAID if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Meclofenamate with Mesalamine?
MediHelp rates the interaction as moderate. Meclofenamate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may harm the kidney: mesalamine through rare interstitial nephritis and meclofenamate through NSAID-induced reductions in renal blood flow. Together they may raise the risk of renal impairment.
How serious is the interaction between Meclofenamate and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine periodically and ensure adequate hydration. Discontinue the NSAID if renal function worsens.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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