Drug interactions
Meclofenamate + Milnacipran
Severity: Moderate
Meclofenamate and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran reduces platelet serotonin uptake and meclofenamate, an NSAID, impairs platelet function and irritates the gastric mucosa. Together they raise the risk of gastrointestinal and other bleeding above that of either drug alone.
What this interaction means in plain words
Meclofenamate and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (SNRI serotonin depletion plus NSAID COX inhibition) combined with NSAID mucosal injury.
What to do
Monitor for signs of GI bleeding such as melena, anemia or hematemesis, and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Meclofenamate with Milnacipran?
MediHelp rates the interaction as moderate. Meclofenamate and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran reduces platelet serotonin uptake and meclofenamate, an NSAID, impairs platelet function and irritates the gastric mucosa. Together they raise the risk of gastrointestinal and other bleeding above that of either drug alone.
How serious is the interaction between Meclofenamate and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding such as melena, anemia or hematemesis, and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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