Drug interactions
Meclofenamate + Oxaprozin
Severity: Major
Meclofenamate and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are NSAIDs, so taking them together duplicates therapy without added benefit. The combination increases the risk of gastrointestinal ulceration and bleeding, renal injury and hyperkalemia.
What this interaction means in plain words
Meclofenamate and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition affecting platelet function, gastric mucosal protection and renal prostaglandin-dependent perfusion.
What to do
Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Switch if one drug is being replaced by the other and stop the first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Meclofenamate with Oxaprozin?
MediHelp rates the interaction as major. Meclofenamate and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are NSAIDs, so taking them together duplicates therapy without added benefit. The combination increases the risk of gastrointestinal ulceration and bleeding, renal injury and hyperkalemia.
How serious is the interaction between Meclofenamate and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Switch if one drug is being replaced by the other and stop the first.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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