Drug interactions
Meclofenamate + Pemetrexed
Severity: Major
Meclofenamate and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can lower renal clearance of pemetrexed and increase its exposure. This raises the likelihood of myelosuppression, mucositis and renal and gastrointestinal toxicity.
What this interaction means in plain words
Meclofenamate and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Reduced renal elimination of pemetrexed via NSAID effects on renal perfusion and possible competition for tubular secretion.
What to do
Avoid meclofenamate around pemetrexed, holding it from about 2 days before to 2 days after dosing. Use paracetamol or another alternative and monitor renal function and blood counts if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclofenamate and Pemetrexed, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pemetrexed
Frequently asked questions
Can I take Meclofenamate with Pemetrexed?
MediHelp rates the interaction as major. Meclofenamate and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meclofenamate, an NSAID, can lower renal clearance of pemetrexed and increase its exposure. This raises the likelihood of myelosuppression, mucositis and renal and gastrointestinal toxicity.
How serious is the interaction between Meclofenamate and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid meclofenamate around pemetrexed, holding it from about 2 days before to 2 days after dosing. Use paracetamol or another alternative and monitor renal function and blood counts if it cannot be avoided.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
